Cloned (Comment) | Organism |
---|---|
expression of mouse embryonic fibroblasts, and in GLI1-positive AsPC1 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme knockdown by DHCR7 siRNA | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AY9944 | i.e. AY9944, competitive inhibitor of DHCR7 enzyme activity and inductor of DHCR7 expression. It blocks hedgehog signaling upstream of the Gli transcription factors, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum membrane | Dhcr7 is a nine-pass transmembrane protein in the endoplasmic reticulum | Homo sapiens | 5789 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
gene DHCR7 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
neuronal cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Dhcr7 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride, i.e. AY9944, is a competitive inhibitor of DHCR7 enzyme activity and inductor of DHCR7 expression. The DHCR7 expression is also activated by antipsychotic drugs, e.g. clozapine, chlorpromazine, haloperidol, and antidepressants such as imipramine, overview | up |
General Information | Comment | Organism |
---|---|---|
physiological function | Dhcr7 inhibits hedgehog signaling in a Smo-independent manner, overview | Homo sapiens |